Cerebrospinal Fluid Tau Cleaved by Caspase-6 Reflects Brain Levels and Cognition in Aging and Alzheimer Disease
Identifieur interne : 000E32 ( Main/Exploration ); précédent : 000E31; suivant : 000E33Cerebrospinal Fluid Tau Cleaved by Caspase-6 Reflects Brain Levels and Cognition in Aging and Alzheimer Disease
Auteurs : Jasmine Ramcharitar [Canada] ; Steffen Albrecht [Canada] ; Veronica M. Afonso [Canada] ; Vikas Kaushal [Canada] ; David A. Bennett [États-Unis] ; Andrea C. Leblanc [Canada]Source :
- Journal of neuropathology and experimental neurology [ 0022-3069 ] ; 2013.
Abstract
Caspase-6 (Casp6) activation in the brain is implicated early in the pathogenesis of Alzheimer disease (AD). In view of the need for early AD diagnosis, brain Casp6 activity was investigated by measuring Tau cleaved by Casp6 (TauΔCasp6) protein in postmortem cerebrospinal fluid (CSF) of 7 non-cognitively impaired, 5 mild cognitively impaired and 12 mild, moderate and severe AD patients. Levels of TauΔCasp6 in CSF accurately reflected the levels of active Casp6 and TauΔCasp6 detected using immunohistochemistry in hippocampal sections from the same individuals. Levels of CSF TauΔCasp6 significantly correlated with AD severity, and with lower global cognitive scores, mini mental state exam, and episodic, semantic, and working memory scores. Regression analyses suggested that the CSF TauΔCasp6 levels combined with TauΔCasp6 brain pathology predict cognitive performance. These results indicate that CSF TauΔCasp6 levels holds promise as a novel early biomarker of AD.
Url:
DOI: 10.1097/NEN.0b013e3182a0a39f
PubMed: 23965742
PubMed Central: 3777607
Affiliations:
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Bennett</name><affiliation wicri:level="2"><nlm:aff id="A4">Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, Illinois</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A5">Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Illinois</region></placeName><wicri:cityArea>Department of Neurological Sciences, Rush University Medical Center, Chicago</wicri:cityArea></affiliation></author><author><name sortKey="Leblanc, Andrea C" sort="Leblanc, Andrea C" uniqKey="Leblanc A" first="Andrea C." last="Leblanc">Andrea C. Leblanc</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec Canada</nlm:aff><orgName type="university">Université McGill</orgName><country>Canada</country><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">The Bloomfield Center for Research in Aging, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>The Bloomfield Center for Research in Aging, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec</wicri:regionArea><wicri:noRegion>Quebec</wicri:noRegion></affiliation></author></analytic><series><title level="j">Journal of neuropathology and experimental neurology</title><idno type="ISSN">0022-3069</idno><idno type="eISSN">1554-6578</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Caspase-6 (Casp6) activation in the brain is implicated early in the pathogenesis of Alzheimer disease (AD). In view of the need for early AD diagnosis, brain Casp6 activity was investigated by measuring Tau cleaved by Casp6 (TauΔCasp6) protein in postmortem cerebrospinal fluid (CSF) of 7 non-cognitively impaired, 5 mild cognitively impaired and 12 mild, moderate and severe AD patients. Levels of TauΔCasp6 in CSF accurately reflected the levels of active Casp6 and TauΔCasp6 detected using immunohistochemistry in hippocampal sections from the same individuals. Levels of CSF TauΔCasp6 significantly correlated with AD severity, and with lower global cognitive scores, mini mental state exam, and episodic, semantic, and working memory scores. Regression analyses suggested that the CSF TauΔCasp6 levels combined with TauΔCasp6 brain pathology predict cognitive performance. These results indicate that CSF TauΔCasp6 levels holds promise as a novel early biomarker of AD.</p></div></front></TEI><affiliations><list><country><li>Canada</li><li>États-Unis</li></country><region><li>Illinois</li><li>Québec</li></region><settlement><li>Montréal</li></settlement><orgName><li>Université McGill</li></orgName></list><tree><country name="Canada"><region name="Québec"><name sortKey="Ramcharitar, Jasmine" sort="Ramcharitar, Jasmine" uniqKey="Ramcharitar J" first="Jasmine" last="Ramcharitar">Jasmine Ramcharitar</name></region><name sortKey="Afonso, Veronica M" sort="Afonso, Veronica M" uniqKey="Afonso V" first="Veronica M." last="Afonso">Veronica M. Afonso</name><name sortKey="Afonso, Veronica M" sort="Afonso, Veronica M" uniqKey="Afonso V" first="Veronica M." last="Afonso">Veronica M. Afonso</name><name sortKey="Albrecht, Steffen" sort="Albrecht, Steffen" uniqKey="Albrecht S" first="Steffen" last="Albrecht">Steffen Albrecht</name><name sortKey="Kaushal, Vikas" sort="Kaushal, Vikas" uniqKey="Kaushal V" first="Vikas" last="Kaushal">Vikas Kaushal</name><name sortKey="Kaushal, Vikas" sort="Kaushal, Vikas" uniqKey="Kaushal V" first="Vikas" last="Kaushal">Vikas Kaushal</name><name sortKey="Leblanc, Andrea C" sort="Leblanc, Andrea C" uniqKey="Leblanc A" first="Andrea C." last="Leblanc">Andrea C. Leblanc</name><name sortKey="Leblanc, Andrea C" sort="Leblanc, Andrea C" uniqKey="Leblanc A" first="Andrea C." last="Leblanc">Andrea C. Leblanc</name><name sortKey="Ramcharitar, Jasmine" sort="Ramcharitar, Jasmine" uniqKey="Ramcharitar J" first="Jasmine" last="Ramcharitar">Jasmine Ramcharitar</name></country><country name="États-Unis"><region name="Illinois"><name sortKey="Bennett, David A" sort="Bennett, David A" uniqKey="Bennett D" first="David A." last="Bennett">David A. Bennett</name></region><name sortKey="Bennett, David A" sort="Bennett, David A" uniqKey="Bennett D" first="David A." last="Bennett">David A. Bennett</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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